Itga6tm1Son
Targeted Allele Detail
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| Symbol: |
Itga6tm1Son |
| Name: |
integrin alpha 6; targeted mutation 1, Arnoud Sonnenberg |
| MGI ID: |
MGI:3050562 |
| Synonyms: |
alpha6A-, Itga6loxP |
| Gene: |
Itga6 Location: Chr2:71617236-71688761 bp, + strand Genetic Position: Chr2, 42.79 cM
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| Alliance: |
Itga6tm1Son page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:50235
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Modified isoform(s)) |
| Mutation: |
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Intragenic deletion
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Mutation details: An exon containing coding sequence specific to the A isoform was deleted by replacement with a loxP-flanked neomycin cassette, followed by cre-mediated recombination in ES cells. This resulted in a single loxP site in place of the exon, and led to the exclusive expression of the B isoform in all tissues where the A isoform was normally expressed.
(J:50235)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Itga6 Mutation: |
211 strains or lines available
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| Original: |
J:50235 Gimond C, et al., Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development. J Cell Biol. 1998 Oct 5;143(1):253-66 |
| All: |
6 reference(s) |
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Analysis Tools
